Dr. Maxence WISZTORSKI
Associate Professor
Laboratoire PRISM - Unité Inserm 1192
Université de Lille - Campus Cité Scientifique
Faculté des Sciences et Technologies
Département de Biologie
Avenue Paul Langevin - Bâtiment SN3 - 1er étage - Porte 121
59655 Villeneuve d'Ascq Cedex
Tel : +33 (0)3 20 43 40 56
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https://orcid.org/0000-0003-1320-075X
ResearcherID: F-4380-2010
Scopus Author ID: 56028414300
Loop profile: 128509
Education
- Since Sept 2007 Associated Professor, University of Lille 1, CNRS FRE 3249, Pr. M. Salze
- Nov. 2006-August 2007 Temporary assistant professor position, University of Lille 1, CNRS-UMR 8017, Pr. M. Salzet
- Oct. 2006 PhD in Proteomics, University of Lille 1, CNRS-UMR 8017 supervised by DR. I. Fournier
Professional Experience
Since 2003 my main research subject was the development of a new technique of molecular imaging based on the MALDI mass spectrometry imaging. The main aspect of this project is to allow direct localization of molecules on a tissue section (frozen or FFPE tissue) by improving the treatment of the tissue along with identification of peptides/proteins. I’m also in charge of the development of a new technique using liquid microjunction extraction and laser ablation droplet capture for the identification of biomarkers involved in ovarian cancers.
Domain of expertise
Mass spectrometry imaging, MALDI Ion source, TOF-TOF and Orbitrap analyzers, Peptides/Proteins identification
Funding
- Partner of project MASDA-EYE (ANR Piribio 2010-2012)
- Partner of project inSIDE (ANR JC 2012-2015)
- Research Subvention 2012 La ligue contre le cancer
Professional Activities
- Member of selection committee for assistant professor recruitment (section 68, since 2010)
- Member of administration committee of university animal housing facility (since 2010)
- Member of the French Mass Spectrometry Society and of the American Society of Mass Spectrometry
- Chairman of the 27th French Mass Spectrometry Conference, 2010
- Associate editor for Journal of Integrated -OMICS
- Journal reviewer: Bioanalysis Bioanalysis
Rapid Communications in Mass Spectrometry
- Oncogene
- Journal of Tissue Science & Engineering
- Journal of Proteomics
- Analytical Chemistry - Grant Review panels and Study sections:
- Association nationale de la Recherche et de la Technologie (ANRT, France) pour les Conventions Industrielles de Formation par la Recherche (CIFRE)
- Fonds pour la Formation à la recherche dans l’industrie et dans l’agriculture (FRIA, belgium) - Student Fellows
- Master Dissertation Committee : 2011, Marie Demeyer, grade légal de Maître en Sciences Chimiques, Chimie Organique, Univ. De Mons, Belgique (rapporteur).
- 2006/11 Mentoring of Masters candidates at FABMS laboratory, University of Lille 1 - Invited Seminars in Foreign Universities
- Interdisciplinary Doctoral School 2012 :Imagery and Mass Spectrometry, Namur, belgium, 2012
Highlights for research activities and significant results
Developments in MALDI Imaging:
- Development of new strategies for identification of molecules on tissue section by using extraction by liquid micro-junction
- Direct tissue analysis by laser ablation droplet capture
- New strategies development for FFPE tissue analysis for clinical studies
- Tissue treatments for proteome analysis
- Development of strategies for HMW proteins localization by MALDI Imaging
- Development of specific mass spectrometry imaging (Tag-Mass) allowing indirect analysis of mRNA, antibodies, large proteins, drugs…
- Fundamental study of sample metallization prior to mass spectrometry analysis
- Development of a new system of mask for increasing the molecular image resolution
Biological applications:
- Application to ovarian cancer for early stage biomarkers characterization
- Studies of neurodegenerative diseases (Parkinson, ALS)
- Neurobiological development
- Study of toxicity of BAK in ophthalmology
- Application to marine biology
- Adaptation of MALDI Imaging to invertebrate model