Charlotte Dubois
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Researcher
Charlotte Dubois is a Research Scientist at INSERM and a member of the PRISM research unit (U1192), where she conducts research on tumor progression and cancer cell plasticity, with a particular focus on prostate cancer. Her work centers on calcium signaling pathways and the role of ORAI family proteins—especially ORAI3—in regulating tumor cell fate, metabolism, and interactions with the tumor microenvironment.
She received her PhD in Cell and Molecular Biology from the University of Lille, where she investigated the oncogenic functions of ORAI calcium channels in prostate cancer (PHYCEL Lab Pr Prevaskaya). She subsequently completed several postdoctoral fellowships, including a position at the VIB–KU Leuven (Belgium) in the laboratory of Prof. Peter Carmeliet, where she studied endothelial metabolism and angiogenesis. She later returned to Lille to develop translational research approaches based on tumor oncograms aimed at predicting chemotherapeutic responses and improving personalized cancer treatments.
Since joining INSERM in 2021 as a Research Scientist, her research has focused on deciphering how ORAI3 contributes to tumor cell plasticity, particularly during neuroendocrine differentiation, and how tumor innervation and other components of the microenvironment influence cancer progression and therapeutic resistance. Her work combines cellular and mouse models with multi-omics approaches and close collaborations with clinical partners.
Charlotte Dubois is actively involved in the supervision of PhD and Master’s students, scientific coordination, and research valorization. Her work has led to publications in international peer-reviewed journals and to patented therapeutic strategies, with the long-term goal of identifying novel targets to overcome resistance in advanced cancers.