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B07-voc-analysis-low-temperature-plasma-mass-spectrometry

B07-voc-analysis-low-temperature-plasma-mass-spectrometry

Isabelle Fournier, Julien Franck, Michel Salzet, Flore Hervé


US 12,712,167 B2 · WO 2021/234319 A1 · FR 3 110 702 A1
https://patents.google.com/patent/US12712167B2/en

Abstract

A system and method for analysing volatile organic compounds adsorbed on an adsorbent membrane. The membrane is held in a receptacle, a low-temperature plasma ioniser directs a plasma stream onto it, desorbing and ionising the adsorbed VOCs and forming a VOC-laden ionised gas, which is transferred to a mass spectrometer.

Because collection is done on a membrane, sampling and analysis are separated in time and no chromatographic separation is required.

Patent family

Publication numberOfficeKindPublished
US 12,712,167 B2United StatesGranted2026-08-18
WO 2021/234319 A1WIPOApplication2021-11-25
FR 3 110 702 A1France — priorityApplication2021-11-26
  • Priority date — 20 May 2020
  • Filing date — 20 May 2021 (PCT)
  • Status — Granted in the United States
  • Applicants — Université de Lille, Inserm, CHRU de Lille
  • Research axis — Ambient & in vivo mass spectrometry

Context

A third ionisation route explored alongside the mid-infrared laser of SpiderMass and the corona discharge of the transfer interfaces. Collecting on a membrane suits volatile compound work, where the sample usually cannot be brought to the instrument.

Abstract as published

A system and method for analyzing volatile organic compounds (VOCs) adsorbed on an adsorbent membrane, by low-temperature plasma and mass spectrometry (LTP-MS). The system includes a receptacle for receiving the adsorbent membrane, a low-temperature plasma ionizer configured to emit a plasma stream in a plasma emission direction, thereby ionizing the VOCs adsorbed by the membrane and forming a VOC-laden ionized gas, and a mass spectrometer for analyzing the ionized VOCs.