B08-device-for-real-time-in-vivo-molecular-analysis-spidermass
Benoît Fatou, Cristian Focsa, Isabelle Fournier, Michel Salzet, Maxence Wisztorski, Michael Ziskind
WO 2016/046748 A1 · FR 3 026 189 A1 · AU 2015323373 B2 · NZ 730251 B2 · CA 2 961 491 A1 · HU E063425 T2
https://patents.google.com/patent/WO2016046748A1/en
Abstract
The SpiderMass patent. A device for the real-time molecular analysis of biological material: a laser, optionally driven by an optical parametric oscillator, emits between 2.5 and 12 µm to ablate the material, and a handheld probe carries the analysis fibre to the sample and a transfer tube back to the mass spectrometer.
Mid-infrared ablation excites the water of the tissue rather than heating it bulk, which keeps sampling minimally invasive — the property that makes in vivo and intra-operative use possible.
Patent family
| Publication number | Office | Kind | Published |
|---|---|---|---|
| WO 2016/046748 A1 | WIPO | Application | 2016-03-31 |
| FR 3 026 189 A1 | France — priority | Application | 2016-03-25 |
| AU 2015323373 B2 | Australia | Granted | — |
| NZ 730251 B2 | New Zealand | Granted | 2022-06-28 |
| CA 2 961 491 A1 | Canada | Application | 2016-03-31 |
| HU E063425 T2 | Hungary — validation of the European patent | Granted | 2024-01-28 |
- Priority date — 22 September 2014
- Filing date — 22 September 2015
- Status — Granted (AU, NZ, EP/HU)
- Applicants — CNRS, Université de Lille
- Research axis — Ambient & in vivo mass spectrometry
Context
The foundation of the laboratory’s ambient and in vivo mass spectrometry line. The proof of concept was published as Fatou et al., In vivo real-time mass spectrometry for guided surgery application, Scientific Reports, 2016. The transfer interfaces WO 2024/170859 and WO 2024/170860, and the dermatology application FR 3 163 166, all build on this device.
Abstract as published
The invention relates to a device for molecular analysis of biological material comprising: a laser (34), possibly assisted by an optical parametric oscillator (OPO), configured to emit a wavelength of between 2.5 and 12 µm, said laser thus configured being intended to ablate said biological material by ejecting charged and/or uncharged particles; a mass spectrometer (31); and a probe (S, 10) comprising at least a first analysis fibre (A, 14) connected to the laser, and a transfer tube (T, 21) connected to the mass spectrometer.