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B11-matrices-for-mass-spectrometry-imaging
Isabelle Fournier, Michel Salzet, Céline Mériaux, Julien Franck
WO 2011/073740 A1
https://patents.google.com/patent/WO2011073740A1/en
Abstract
Liquid ionic matrices for MALDI mass spectrometry imaging of tissue sections. The matrices combine 2,5-dihydroxybenzoic acid with an organic base; the liquid matrix wets the section homogeneously and limits the delocalisation of analytes during deposition, which improves the detection and the localisation of species such as lipids.
Patent family
| Publication number | Office | Kind | Published |
|---|---|---|---|
| WO 2011/073740 A1 | WIPO | Application | 2011-06-23 |
- Priority date — 15 December 2009
- Filing date — 15 December 2009
- Status — To be confirmed
- Applicants — CNRS, Université des Sciences et Technologies de Lille
- Research axis — Sample preparation & MALDI matrices
Context
Follows the solid ionic matrices of US 2008/0203289: from a solid salt to a liquid matrix, and from proteins to lipids.
Abstract as published
Liquid ionic matrices for MALDI Mass Spectrometry Imaging (MALDI-MSI) of tissue sections and their use for the detection and localization of analytes such as lipids. The matrices comprise 2,5-dihydroxybenzoic acid and an organic base so as to reduce delocalization of analytes.